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Research Highlights

4D Microscopy & Diffraction | Theory & Computation | Video

Femtobiology

Femtochemistry

Research in femtobiology has, over the years, focused on understanding the nature of the elementary processes involved in the function of macromolecular structures. These processes include folding-unfolding, hydration, electron (proton) transfer, molecular recognition, and enzyme catalysis. Here, we highlight such studies from selected publications (see abstracts below).


Selected Publications

Speed limit of protein folding evidenced in secondary structure dynamics, M. M. Lin, O. F. Mohammed, G. S. Jas, A. H. Zewail, Proc. Natl. Acad. Sci. USA 2011, 108, 16622-16627.
[Web link] [Abstract] [Top of page]



Biological water: A critique, D. Zhong, S. K. Pal, A. H. Zewail, Chem. Phys. Lett. 2011, 503, 1-11.
[Web link] [Abstract] [Top of page]



Hydration dynamics at fluorinated protein surfaces, O.-H. Kwon, T. H. Yoo, C. M. Othon, J. A. Van Deventer, D. A. Tirrell, A. H. Zewail, Proc. Natl. Acad. Sci. USA 2010, 107, 17101-17106.
[Web link] [Abstract] [Top of page]



Primary peptide folding dynamics observed with ultrafast temperature jump, O. F. Mohammed, G. S. Jas, M. M. Lin, A. H. Zewail, Angew. Chem., Int. Ed. Engl. 2009, 48, 5628-5632.
[Web link] [Abstract] [Top of page]



DNA folding and melting in real time: Observed collapsed structures redefine the energy landscape, H. Ma, C. Wan, A. Wu, A. H. Zewail, Proc. Natl. Acad. Sci. USA 2007, 104, 712-716.
[Web link] [Abstract] [Top of page]



Ultrafast T-jump in water: Studies of conformation and reaction dynamics at the thermal limit, H. Ma, C. Wan, A. H. Zewail, J. Am. Chem. Soc. 2006, 128, 6338-6340.
[Web link] [Abstract] [Top of page]



Protein surface hydration mapped by site-specific mutations, W. Qiu, Y. Kao, L. Zhang, Y. Yang, L. Wang, W. E. Stites, D. Zhong, A. H. Zewail, Proc. Natl. Acad. Sci. USA 2006, 103, 13979-13984.
[Web link] [Abstract] [Top of page]



RNA-protein recognition: Single-residue ultrafast dynamical control of structural specificity and function, T. Xia, C. Wan, R. W. Roberts, A. H. Zewail, Proc. Natl. Acad. Sci. USA 2005, 102, 13013-13018.
[Web link] [Abstract] [Top of page]



Enzyme functionality and solvation of subtilisin Carlsberg: From hours to femtoseconds, J. K. A. Kamal, T. Xia, S. K. Pal, L. Zhao, A. H. Zewail, Chem. Phys. Lett. 2004, 387, 209-215.
[Web link] [Abstract] [Top of page]



Dynamics of water in biological recognition, S. K. Pal, A. H. Zewail, Chem. Rev. 2004, 104, 2099-2123.
[Web link] [Abstract] [Top of page]



Ultrafast dynamics in DNA-mediated electron transfer: Base gating and the role of temperature, M. A. O'Neill, H.-C. Becker, C. Wan, J. K. Barton, A. H. Zewail, Angew. Chem., Int. Ed. Engl. 2003, 42, 5896-5900.
[Web link] [Abstract] [Top of page]



Femtosecond molecular dynamics of tautomerization in model base pairs, A. Douhal, S. K. Kim, A. H. Zewail, Nature 1995, 378, 260-263.
[Web link] [Abstract] [See also] [Top of page]