|
Research in femtobiology has, over
the years, focused on understanding the nature of the elementary
processes involved in the function of macromolecular
structures. These processes include folding-unfolding, hydration,
electron (proton) transfer, molecular recognition, and enzyme
catalysis. Here, we highlight such studies from selected
publications (see abstracts below).
|
|
Selected Publications
|
DNA folding and melting in real time:
Observed collapsed structures redefine the energy landscape, H. Ma,
C. Wan, A. Wu, A. H. Zewail, Proc.
Natl. Acad. Sci. USA 2007, 104, 712-716.
[Web link] [Abstract] [Top of page]
|
|
|
Ultrafast T-jump in water: Studies of
conformation and reaction dynamics at the thermal limit, H. Ma, C. Wan,
A. H. Zewail, J.
Am. Chem. Soc. 2006, 128, 6338-6340.
[Web
link] [Abstract] [Top of page]
|
|
|
Protein surface hydration mapped by
site-specific mutations, W. Qiu, Y. Kao, L. Zhang, Y. Yang, L. Wang,
W. E. Stites, D. Zhong, A. H. Zewail, Proc. Natl. Acad. Sci. USA 2006, 103,
13979-13984.
[Web link] [Abstract] [Top of page]
|
|
|
RNA-protein recognition: Single-residue
ultrafast dynamical control of structural specificity and function, T. Xia,
C. Wan, R. W. Roberts, A. H. Zewail, Proc. Natl. Acad. Sci. USA
2005, 102, 13013-13018.
[Web link] [Abstract] [Top of page]
|
|
|
Enzyme functionality and solvation of subtilisin Carlsberg: From hours to femtoseconds, J. K. A. Kamal, T. Xia, S. K. Pal, L. Zhao, A. H. Zewail, Chem. Phys. Lett.
2004, 387, 209-215.
[Web link] [Abstract] [Top of page]
|
|
|
Dynamics of water in biological
recognition, S. K. Pal, A. H. Zewail, Chem.
Rev. 2004, 104, 2099-2123.
[Web link] [Abstract] [Top of page]
|
|
|
Ultrafast dynamics in DNA-mediated electron
transfer: Base gating and the role of temperature, M. A. O'Neill, H.-C. Becker, C. Wan, J. K. Barton, A. H. Zewail, Angew. Chem., Int. Ed. Engl.
2003, 42, 5896-5900.
[Web link] [Abstract] [Top of page]
|
|
|
Femtosecond molecular dynamics of tautomerization in model base pairs, A. Douhal, S. K. Kim, A. H. Zewail, Nature
1995, 378, 260-263.
[Web link] [Abstract]
[See also] [Top of page]
|
|
|
|
